Kisspeptin
A naturally occurring neuropeptide that plays a central role in reproductive hormone regulation and fertility.
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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
What is Kisspeptin?
Kisspeptin is a naturally occurring neuropeptide that acts as a master regulator of the reproductive hormone axis. It stimulates the release of GnRH (gonadotropin-releasing hormone), which in turn triggers the release of LH and FSH — the hormones that drive testosterone and estrogen production. Multiple randomized controlled trials have demonstrated its efficacy as an IVF oocyte maturation trigger, and clinical studies show it can modulate sexual desire via brain processing pathways.
Why People Talk About It
IVF oocyte maturation trigger (safer OHSS alternative)
StrongSexual desire and arousal (HSDD)
ModerateReproductive hormone regulation
StrongPuberty diagnostics and intervention
EmergingHow It Works
Kisspeptin acts as the master switch for your reproductive hormones. It tells the brain to release the signals that ultimately lead to testosterone and estrogen production. It sits at the very top of the hormonal cascade.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Active clinical research compound
- • Hormonal effects require monitoring
- • Not FDA-approved for therapeutic use
What We Don't Know
Optimal dosing, long-term effects, and clinical applications are still being established through ongoing research.
Published Research
49 studiesAssociations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome
Sex Differences in Leptin Levels in Children and Adolescents with Normal Weight and Overweight/Obesity Across Pubertal Stages: A Systematic Review and Meta-analysis
Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis
An association between fat mass and obesity-associated (FTO) (rs9939609) and kisspeptin-1 (KISS-1) (rs4889, rs372790354) gene polymorphisms with polycystic ovary syndrome: an updated meta-analysis and power analysis
Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis
Serum kisspeptin levels in polycystic ovary syndrome: A meta-analysis
Preeclampsia and gestational hypertension are associated to low maternal circulating kisspeptin levels: a systematic review and meta-analysis
Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression
Outcomes comparison of IVF/ICSI among different trigger methods for final oocyte maturation: A systematic review and meta-analysis
Kisspeptin Levels in Girls with Precocious Puberty: A Systematic Review and Meta-Analysis
The role of Kisspeptin levels in polycystic ovary syndrome: a systematic review and meta-analysis
Circulatory metastin/kisspeptin-1 in polycystic ovary syndrome: a systematic review and meta-analysis with diagnostic test accuracy
Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans
Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans
Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study
Kisspeptin expression levels in patients with placenta previa: A randomized trial
Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricals
Oral sodium oxybate does not alter plasma kisspeptin levels in healthy male volunteers
Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial
Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial
Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men
Green tea catechin EGCG could prevent obesity-related precocious puberty through NKB/NK3R signaling pathway
Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women
Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome
The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men
Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects
Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men
Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome
The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans
Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions
The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.
Metabolic regulation of kisspeptin - the link between energy balance and reproduction.
Kisspeptin and Glucose Homeostasis.
Kisspeptin in the Prediction of Pregnancy Complications.
Kisspeptin as a Behavioral Hormone.
A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.
Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy.
Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.
Divergent responses to kisspeptin in children with delayed puberty.
Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty.
Kisspeptin and its Current Clinical Status-A Systematic Review.
The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.
Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes.
Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males.
Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women.
Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.
Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea.
Kisspeptin modulates sexual and emotional brain processing in humans.
Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome.
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
Related Peptides
Quick Facts
- Class
- Neuropeptide
- Evidence
- Moderate
- Safety
- Moderate Data
- Updated
- Mar 2026
- Citations
- 49PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
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