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Kisspeptin

A naturally occurring neuropeptide that plays a central role in reproductive hormone regulation and fertility.

ModerateModerate Data

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

What is Kisspeptin?

Kisspeptin is a naturally occurring neuropeptide that acts as a master regulator of the reproductive hormone axis. It stimulates the release of GnRH (gonadotropin-releasing hormone), which in turn triggers the release of LH and FSH — the hormones that drive testosterone and estrogen production. Multiple randomized controlled trials have demonstrated its efficacy as an IVF oocyte maturation trigger, and clinical studies show it can modulate sexual desire via brain processing pathways.

Why People Talk About It

IVF oocyte maturation trigger (safer OHSS alternative)

Strong

Sexual desire and arousal (HSDD)

Moderate

Reproductive hormone regulation

Strong

Puberty diagnostics and intervention

Emerging

How It Works

Kisspeptin acts as the master switch for your reproductive hormones. It tells the brain to release the signals that ultimately lead to testosterone and estrogen production. It sits at the very top of the hormonal cascade.

Common Questions

Safety Information

Important Safety Notes

Common Side Effects

Injection site reactionsPotential hormonal fluctuations

Cautions

  • Active clinical research compound
  • Hormonal effects require monitoring
  • Not FDA-approved for therapeutic use

What We Don't Know

Optimal dosing, long-term effects, and clinical applications are still being established through ongoing research.

Published Research

49 studies

Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome

Meta-AnalysisPMID: 40704698

Sex Differences in Leptin Levels in Children and Adolescents with Normal Weight and Overweight/Obesity Across Pubertal Stages: A Systematic Review and Meta-analysis

Meta-AnalysisPMID: 41240372

Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis

Meta-AnalysisPMID: 39468787

An association between fat mass and obesity-associated (FTO) (rs9939609) and kisspeptin-1 (KISS-1) (rs4889, rs372790354) gene polymorphisms with polycystic ovary syndrome: an updated meta-analysis and power analysis

Meta-AnalysisPMID: 39126595

Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis

Meta-AnalysisPMID: 35212930

Serum kisspeptin levels in polycystic ovary syndrome: A meta-analysis

Meta-AnalysisPMID: 33765692

Preeclampsia and gestational hypertension are associated to low maternal circulating kisspeptin levels: a systematic review and meta-analysis

Meta-AnalysisPMID: 34779331

Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

Meta-AnalysisPMID: 33744505

Outcomes comparison of IVF/ICSI among different trigger methods for final oocyte maturation: A systematic review and meta-analysis

Meta-AnalysisPMID: 34085322

Kisspeptin Levels in Girls with Precocious Puberty: A Systematic Review and Meta-Analysis

Meta-AnalysisPMID: 33887744

The role of Kisspeptin levels in polycystic ovary syndrome: a systematic review and meta-analysis

Meta-AnalysisPMID: 31584133

Circulatory metastin/kisspeptin-1 in polycystic ovary syndrome: a systematic review and meta-analysis with diagnostic test accuracy

Meta-AnalysisPMID: 31515170

Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans

Randomized Controlled TrialPMID: 40215751

Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans

Randomized Controlled TrialPMID: 40036336

Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study

Randomized Controlled TrialPMID: 39847034

Kisspeptin expression levels in patients with placenta previa: A randomized trial

Randomized Controlled TrialPMID: 38996103

Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricals

Randomized Controlled TrialPMID: 37925096

Oral sodium oxybate does not alter plasma kisspeptin levels in healthy male volunteers

Randomized Controlled TrialPMID: 37401623

Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial

Randomized Controlled TrialPMID: 36735255

Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial

Randomized Controlled TrialPMID: 36287566

Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men

Randomized Controlled TrialPMID: 35244717

Green tea catechin EGCG could prevent obesity-related precocious puberty through NKB/NK3R signaling pathway

Randomized Controlled TrialPMID: 35691596

Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women

Randomized Controlled TrialPMID: 33624806

Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome

Randomized Controlled TrialPMID: 34000049

The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men

Randomized Controlled TrialPMID: 33075807

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

Randomized Controlled TrialPMID: 33045853

Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men

Randomized Controlled TrialPMID: 32051344

Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome

Randomized Controlled TrialPMID: 32510130

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans

Randomized Controlled TrialPMID: 29974637

Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions

Randomized Controlled TrialPMID: 30333302

The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.

ReviewPMID: 35837314

Metabolic regulation of kisspeptin - the link between energy balance and reproduction.

ReviewPMID: 32427949

Kisspeptin and Glucose Homeostasis.

ReviewPMID: 31869842

Kisspeptin in the Prediction of Pregnancy Complications.

ReviewPMID: 35928889

Kisspeptin as a Behavioral Hormone.

ReviewPMID: 31847025

A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.

Randomized Controlled TrialPMID: 28854728

Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy.

Randomized Controlled TrialPMID: 26192876

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.

Clinical TrialPMID: 25036713

Divergent responses to kisspeptin in children with delayed puberty.

Clinical TrialPMID: 29669934

Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty.

Clinical TrialPMID: 27214398

Kisspeptin and its Current Clinical Status-A Systematic Review.

Systematic ReviewPMID: 38265397

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.

ReviewPMID: 37467734

Lower circulating kisspeptin and primary hypogonadism in men with type 2 diabetes.

Observational StudyPMID: 34505408

Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males.

Clinical TrialPMID: 16174713

Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women.

Clinical TrialPMID: 17635940

Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.

Randomized Controlled TrialPMID: 19820030

Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea.

Randomized Controlled TrialPMID: 20980998

Kisspeptin modulates sexual and emotional brain processing in humans.

Randomized Controlled TrialPMID: 28112678

Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome.

Clinical TrialPMID: 31820802

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

Related Peptides

Quick Facts

Class
Neuropeptide
Evidence
Moderate
Safety
Moderate Data
Updated
Mar 2026
Citations
49PubMed

Also known as

Kisspeptin-10Kisspeptin-54Metastin

Tags

HormonalFertilityReproductive HealthResearch

Related Goals

Evidence Score

Overall Confidence62%

Clinical Trials

View Clinical Trials

Links to ClinicalTrials.gov for reference. Listing does not imply endorsement.

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