N-Acetyl Epithalon Amidate
An enhanced version of Epithalon with improved stability, studied for telomerase activation, pineal gland regulation, and anti-aging effects.
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
What is N-Acetyl Epithalon Amidate?
N-Acetyl Epithalon Amidate is a modified version of Epithalon (epitalon), the synthetic tetrapeptide Ala-Glu-Asp-Gly, with N-acetyl and C-amide terminal modifications that improve enzymatic stability and potentially enhance bioavailability. Epithalon was originally identified as a synthetic analogue of the pineal gland peptide epithalamin by Professor Vladimir Khavinson's research group. It is studied for its ability to activate telomerase, regulate melatonin synthesis, stimulate neurogenesis, and potentially slow cellular aging.
Why People Talk About It
Enhanced telomerase activation vs standard Epithalon
PreliminaryImproved stability and bioavailability
PreliminaryAnti-aging and longevity support
PreliminaryPineal gland function and melatonin regulation
PreliminaryNeuroprotective and neurogenic effects
PreliminaryRetinal health and retinitis pigmentosa support
PreliminaryHow It Works
This is a more stable version of Epithalon that may activate telomerase more effectively. Telomerase rebuilds the protective caps (telomeres) on your chromosomes that shorten with age, potentially slowing cellular aging. It also supports pineal gland function and melatonin production, which decline with age.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Not FDA-approved
- • Very limited human data
- • Theoretical concerns about telomerase activation in cancer cells
What We Don't Know
Safety data specific to the N-acetyl amidate form is essentially nonexistent. Extrapolated from Epithalon data. Long-term effects of chronic telomerase activation in humans remain unstudied.
Published Research
17 studiesOverview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Epitalon-activated telomerase enhances bovine oocyte maturation rate and post-thawed embryo development
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line
Epigenetic Modification Under the Influence of Peptide Bioregulators on the 'Old' Chromatin
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Effect of short peptides on neuronal differentiation of stem cells
Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland
Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa
Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas
Peptide promotes overcoming of the division limit in human somatic cell
Effect of regulatory peptides on gene transcription
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
Related Peptides
Quick Facts
- Class
- Bioregulator Peptide
- Evidence
- Preliminary
- Safety
- Limited Data
- Updated
- Mar 2026
- Citations
- 17PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
Interested in this peptide? A Noho clinician can help determine if it's right for you.
Talk to a Clinician