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TB-500

A synthetic version of the active region of thymosin beta-4, widely used for tissue repair, wound healing, and recovery from injuries.

EmergingModerate Data Beginner-Friendly

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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

What is TB-500?

TB-500 is a synthetic version of the active region of thymosin beta-4, a naturally occurring 43-amino acid peptide present in virtually all human cells. It promotes tissue repair by upregulating actin, a cell-building protein, and by promoting cell migration, blood vessel formation, and reducing inflammation. It is one of the most popular peptides for injury recovery.

Why People Talk About It

Accelerated wound and tissue healing

Emerging

Tendon and ligament repair

Emerging

Muscle recovery and repair

Preliminary

Reduced inflammation and fibrosis

Emerging

Cardiac tissue repair

Emerging

Hair regrowth

Preliminary

How It Works

TB-500 helps your body repair itself faster by promoting the migration of repair cells to injury sites, growing new blood vessels to supply healing tissue, and reducing scar formation. It works on tendons, ligaments, muscles, skin, and even the heart.

Common Questions

Safety Information

Important Safety Notes

Common Side Effects

Injection site rednessMild headacheTemporary lethargy

Cautions

  • Not FDA-approved
  • Theoretical concern about promoting growth of existing tumors
  • Banned by WADA in competitive sports

What We Don't Know

Long-term safety in humans is not well-established. Cancer risk with chronic use needs more study.

Published Research

38 studies

Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues

Comparative StudyPMID: 6954532

Chemical characterization of thymosin beta 4

Comparative StudyPMID: 7054160

Thymosin β(4) and β(10) Expression in Human Organs during Development: A Review

ReviewPMID: 38994967

Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies

ReviewPMID: 34071596

Thymosin beta 4 and the eye: the journey from bench to bedside

ReviewPMID: 30063853

Thymosin beta 4 regulation of actin in sepsis

ReviewPMID: 29508629

Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations

ReviewPMID: 29502471

Potential role of thymosin beta 4 in the treatment of nonalcoholic fatty liver disease

ReviewPMID: 29063072

Cardioprotection by Thymosin Beta 4

ReviewPMID: 27450736

Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells

ReviewPMID: 27450733

Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases

ReviewPMID: 27450739

Potential role of thymosin Beta 4 in liver fibrosis

ReviewPMID: 26006229

Adhesive and proteolytic phenotype of migrating endothelial cells induced by thymosin beta-4

ReviewPMID: 17495245

Thymosin beta-4 and the eye: I can see clearly now the pain is gone

ReviewPMID: 17495249

Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium

ReviewPMID: 17495252

Thymosin beta 4 interactions

ReviewPMID: 12852258

Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications

ReviewPMID: 22074294

Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies

ReviewPMID: 36709593

Doping control analysis of TB-500, a synthetic version of an active fragment of thymosin β₄.

ReviewPMID: 23084823

Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids

PreclinicalPMID: 40816274

Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion

PreclinicalPMID: 41229390

Thymosin Beta-4 Modulates Cardiac Remodeling by Regulating ROCK1 Expression in Adult Mammals

PreclinicalPMID: 40362372

Enhancing fat graft survival: thymosin beta-4 facilitates mitochondrial transfer from ADSCs via tunneling nanotubes by upregulating the Rac/F-actin pathway

PreclinicalPMID: 39761767

Thymosin beta-4 participate in antibacterial immunity and wound healing in black tiger shrimp, Penaeus monodon

PreclinicalPMID: 37689229

Thymosin Beta 4 Inhibits LPS and ATP-Induced Hepatic Stellate Cells via the Regulation of Multiple Signaling Pathways

PreclinicalPMID: 36834849

Thymosin beta 4: A potential novel adjunct treatment for bacterial keratitis

PreclinicalPMID: 37018981

Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice

PreclinicalPMID: 36878045

Thymosin Beta 4 Protects Hippocampal Neuronal Cells against PrP (106-126) via Neurotrophic Factor Signaling

PreclinicalPMID: 37175330

Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals

PreclinicalPMID: 38706788

Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer

PreclinicalPMID: 36321670

Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells

PreclinicalPMID: 35012642

Adjunctive Thymosin Beta-4 Treatment Influences PMN Effector Cell Function during Pseudomonas aeruginosa-Induced Corneal Infection

PreclinicalPMID: 34944086

Thymosin beta4 accelerates wound healing

PreclinicalPMID: 10469335

Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development.

PreclinicalPMID: 15037013

Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5

PreclinicalPMID: 28887173

Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential

PreclinicalPMID: 22962027

Thymosin β4 Promotes Dermal Healing

Clinical TrialPMID: 27450738

A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin β4 in healthy Chinese volunteers

Clinical Trial, Phase IPMID: 34346165

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

Related Peptides

Quick Facts

Class
Tissue Repair Peptide
Evidence
Emerging
Safety
Moderate Data
Updated
Mar 2026
Citations
38PubMed

Also known as

Thymosin Beta-4Tβ4TB4 FragmentAc-SDKP

Tags

RecoveryWound HealingAnti-InflammatoryTissue Repair

Related Goals

Evidence Score

Overall Confidence50%

Clinical Trials

View Clinical Trials

Links to ClinicalTrials.gov for reference. Listing does not imply endorsement.

Clinician Guided

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