TB-500
A synthetic version of the active region of thymosin beta-4, widely used for tissue repair, wound healing, and recovery from injuries.
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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
What is TB-500?
TB-500 is a synthetic version of the active region of thymosin beta-4, a naturally occurring 43-amino acid peptide present in virtually all human cells. It promotes tissue repair by upregulating actin, a cell-building protein, and by promoting cell migration, blood vessel formation, and reducing inflammation. It is one of the most popular peptides for injury recovery.
Why People Talk About It
Accelerated wound and tissue healing
EmergingTendon and ligament repair
EmergingMuscle recovery and repair
PreliminaryReduced inflammation and fibrosis
EmergingCardiac tissue repair
EmergingHair regrowth
PreliminaryHow It Works
TB-500 helps your body repair itself faster by promoting the migration of repair cells to injury sites, growing new blood vessels to supply healing tissue, and reducing scar formation. It works on tendons, ligaments, muscles, skin, and even the heart.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Not FDA-approved
- • Theoretical concern about promoting growth of existing tumors
- • Banned by WADA in competitive sports
What We Don't Know
Long-term safety in humans is not well-established. Cancer risk with chronic use needs more study.
Published Research
38 studiesThymosin beta 4: a ubiquitous peptide in rat and mouse tissues
Chemical characterization of thymosin beta 4
Thymosin β(4) and β(10) Expression in Human Organs during Development: A Review
Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies
Thymosin beta 4 and the eye: the journey from bench to bedside
Thymosin beta 4 regulation of actin in sepsis
Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations
Potential role of thymosin beta 4 in the treatment of nonalcoholic fatty liver disease
Cardioprotection by Thymosin Beta 4
Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases
Potential role of thymosin Beta 4 in liver fibrosis
Adhesive and proteolytic phenotype of migrating endothelial cells induced by thymosin beta-4
Thymosin beta-4 and the eye: I can see clearly now the pain is gone
Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium
Thymosin beta 4 interactions
Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies
Doping control analysis of TB-500, a synthetic version of an active fragment of thymosin β₄.
Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids
Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion
Thymosin Beta-4 Modulates Cardiac Remodeling by Regulating ROCK1 Expression in Adult Mammals
Enhancing fat graft survival: thymosin beta-4 facilitates mitochondrial transfer from ADSCs via tunneling nanotubes by upregulating the Rac/F-actin pathway
Thymosin beta-4 participate in antibacterial immunity and wound healing in black tiger shrimp, Penaeus monodon
Thymosin Beta 4 Inhibits LPS and ATP-Induced Hepatic Stellate Cells via the Regulation of Multiple Signaling Pathways
Thymosin beta 4: A potential novel adjunct treatment for bacterial keratitis
Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice
Thymosin Beta 4 Protects Hippocampal Neuronal Cells against PrP (106-126) via Neurotrophic Factor Signaling
Thymosin beta-4 - A potential tool in healing middle ear lesions in adult mammals
Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer
Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells
Adjunctive Thymosin Beta-4 Treatment Influences PMN Effector Cell Function during Pseudomonas aeruginosa-Induced Corneal Infection
Thymosin beta4 accelerates wound healing
Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development.
Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5
Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential
Thymosin β4 Promotes Dermal Healing
A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin β4 in healthy Chinese volunteers
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
Related Peptides
Quick Facts
- Class
- Tissue Repair Peptide
- Evidence
- Emerging
- Safety
- Moderate Data
- Updated
- Mar 2026
- Citations
- 38PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
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