AOD-9604
A modified fragment of human growth hormone studied specifically for fat metabolism without the growth-promoting effects of full GH.
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What is AOD-9604?
AOD-9604 is a modified fragment of human growth hormone (specifically amino acids 177-191 with an added tyrosine). It was designed to isolate the fat-metabolizing properties of growth hormone without its growth-promoting effects. It received GRAS (Generally Recognized as Safe) status from the FDA as a food additive, though it is not approved as a drug.
Why People Talk About It
Fat metabolism without GH side effects
EmergingBody composition improvement
PreliminaryCartilage repair (emerging research)
PreliminaryHow It Works
AOD-9604 is a small piece of growth hormone that appears to stimulate fat breakdown (lipolysis) and inhibit fat formation (lipogenesis) without affecting blood sugar or growth. It targets fat cells specifically.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Not FDA-approved as a drug
- • Clinical trial results for obesity were not conclusive enough for drug approval
- • Quality varies between sources
What We Don't Know
The Phase IIb clinical trial for obesity did not meet its primary endpoint, which raises questions about efficacy at studied doses.
Published Research
6 studiesAOD-9604 Metabolic
AOD-9604 does not influence the WADA hGH isoform immunoassay
Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone
Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment.
Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism.
The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
Research Insights
Related Peptides
Quick Facts
- Class
- GH Fragment
- Evidence
- Emerging
- Safety
- Moderate Data
- Updated
- Jan 2026
- Citations
- 6PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
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