CJC-1295
A growth hormone-releasing hormone analog that stimulates the pituitary gland to produce more growth hormone.
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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
What is CJC-1295?
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH). It works by stimulating the pituitary gland to release growth hormone in a pulsatile, physiological manner. It comes in two forms: with DAC (Drug Affinity Complex) for extended release, and without DAC (also called Modified GRF 1-29) for shorter-acting pulses. It is one of the most commonly discussed peptides for growth hormone optimization.
Why People Talk About It
Growth hormone optimization
ModerateImproved body composition
ModerateEnhanced recovery from exercise
EmergingImproved sleep quality
EmergingAnti-aging support
PreliminaryHow It Works
CJC-1295 mimics a natural hormone in your body that tells the pituitary gland to release growth hormone. By extending this signal, it helps maintain higher, more youthful levels of growth hormone, which plays a role in recovery, body composition, and overall vitality.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Not FDA-approved
- • Should be monitored with IGF-1 blood tests
- • Not appropriate for those with active cancer
- • May affect blood sugar regulation
What We Don't Know
Long-term effects of sustained growth hormone elevation are an area of ongoing research. The optimal duration of use is not well established.
Published Research
12 studiesProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog
Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men
Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions
Glycine-modified growth hormone secretagogues identified in seized doping material
A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS
An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma
Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation
Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
Incorporation of D-Ala2 in growth hormone-releasing hormone-(1-29)-NH2 increases the half-life and decreases metabolic clearance in normal men
Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
Research Insights
Related Peptides
Ipamorelin
ModerateBeginnerA selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin.
Sermorelin
StrongBeginnerA growth hormone-releasing hormone analog that was previously FDA-approved for diagnosing GH deficiency in children.
Tesamorelin
StrongAn FDA-approved GHRH analog used to reduce visceral fat in HIV-associated lipodystrophy.
MK-677
ModerateAn orally active growth hormone secretagogue that mimics ghrelin to stimulate GH and IGF-1 release.
Quick Facts
- Class
- GHRH Analog
- Evidence
- Moderate
- Safety
- Moderate Data
- Updated
- Feb 2026
- Citations
- 12PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
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