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Teduglutide

An FDA-approved GLP-2 analogue that promotes intestinal growth, used for short bowel syndrome.

StrongWell-Studied

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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

What is Teduglutide?

Teduglutide is a GLP-2 (glucagon-like peptide-2) analogue that promotes intestinal mucosal growth and adaptation. It is FDA-approved for adults and children with short bowel syndrome (SBS) who are dependent on parenteral nutrition. It is the first drug to address the underlying intestinal insufficiency rather than just managing symptoms.

Why People Talk About It

Short bowel syndrome treatment

Strong

Reducing parenteral nutrition dependence

Strong

Intestinal mucosal growth and repair

Strong

How It Works

Teduglutide tells the intestinal lining to grow. For patients who have lost most of their intestine, it helps the remaining gut tissue become more efficient at absorbing nutrients and fluids.

Common Questions

Safety Information

Important Safety Notes

Common Side Effects

Abdominal painNauseaInjection site reactionsFluid overload (as absorption improves)

Cautions

  • Requires colonoscopy before and during treatment (theoretical polyp risk)
  • Monitor for biliary and pancreatic disease
  • Adjust parenteral nutrition as absorption improves

What We Don't Know

Long-term effects on intestinal neoplasia risk are being monitored through registries.

Published Research

31 studies

Positive clinical outcomes associated with use of glucagon-like peptide-2 (GLP-2) analogues in patients with intestinal failure: A systematic review and meta-analysis

Meta-AnalysisPMID: 41344401

Efficacy and safety of glucagon-like peptide 2 in patients with short bowel syndrome: a systematic review and network meta-analysis

Meta-AnalysisPMID: 38663565

[Review of real-life teduglutide experience]

Meta-AnalysisPMID: 37409717

Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis

Meta-AnalysisPMID: 35215445

Population pharmacokinetics of teduglutide following repeated subcutaneous administrations in healthy participants and in patients with short bowel syndrome and Crohn's disease

Meta-AnalysisPMID: 19773525

Use of Teduglutide in Children With Intestinal Failure: A Systematic Review

Systematic ReviewPMID: 35774551

Teduglutide for Safe Reduction of Parenteral Nutrient and/or Fluid Requirements in Adults: A Systematic Review

Systematic ReviewPMID: 25883117

Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration

Randomized Controlled TrialPMID: 39662176

Teduglutide improves liver chemistries in short bowel syndrome-associated intestinal failure: Post hoc analysis

Randomized Controlled TrialPMID: 38491966

Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial

Randomized Controlled TrialPMID: 38632262

Efficacy and Safety of Teduglutide in Infants and Children With Short Bowel Syndrome Dependent on Parenteral Support

Randomized Controlled TrialPMID: 37364133

Teduglutide for the treatment of low-output enterocutaneous fistula - A pilot randomized controlled study

Randomized Controlled TrialPMID: 35871951

Citrulline correlations in short bowel syndrome-intestinal failure by patient stratification: Analysis of 24 weeks of teduglutide treatment from a randomized controlled study

Randomized Controlled TrialPMID: 31784300

Impact of Teduglutide on Quality of Life Among Patients With Short Bowel Syndrome and Intestinal Failure

Randomized Controlled TrialPMID: 31006876

Glucagon-like peptide-2 mobilizes lipids from the intestine by a systemic nitric oxide-independent mechanism

Randomized Controlled TrialPMID: 31364232

Reduction of Parenteral Nutrition and Hydration Support and Safety With Long-Term Teduglutide Treatment in Patients With Short Bowel Syndrome-Associated Intestinal Failure: STEPS-3 Study

Randomized Controlled TrialPMID: 29761915

Factors Associated With Response to Teduglutide in Patients With Short-Bowel Syndrome and Intestinal Failure

Randomized Controlled TrialPMID: 29174926

Independence From Parenteral Nutrition and Intravenous Fluid Support During Treatment With Teduglutide Among Patients With Intestinal Failure Associated With Short Bowel Syndrome

Randomized Controlled TrialPMID: 27875291

Patients With Short Bowel on Narcotics During 2 Randomized Trials Have Abdominal Complaints Independent of Teduglutide

Randomized Controlled TrialPMID: 27507402

Acute Effects of a Glucagon-Like Peptide 2 Analogue, Teduglutide, on Gastrointestinal Motor Function and Permeability in Adult Patients With Short Bowel Syndrome on Home Parenteral Nutrition

Randomized Controlled TrialPMID: 26223941

A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects

Randomized Controlled TrialPMID: 24517114

Teduglutide enhances structural adaptation of the small intestinal mucosa in patients with short bowel syndrome

Randomized Controlled TrialPMID: 23426461

Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study

Randomized Controlled TrialPMID: 23587733

Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure

Randomized Controlled TrialPMID: 23333663

Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's disease

Randomized Controlled TrialPMID: 19821509

Pharmacokinetics, safety, and tolerability of teduglutide, a glucagon-like peptide-2 (GLP-2) analog, following multiple ascending subcutaneous administrations in healthy subjects

Randomized Controlled TrialPMID: 18974283

Teduglutide in pediatric patients under 10 kg with short bowel syndrome on parenteral support: An open-label study

Phase III Clinical TrialPMID: 41454663

Effects of Teduglutide on Diarrhea in Pediatric Patients with Short Bowel Syndrome-Associated Intestinal Failure

Phase III Clinical TrialPMID: 37889619

Teduglutide Reduces Need for Parenteral Support Among Patients With Short Bowel Syndrome With Intestinal Failure

Clinical TrialPMID: 22982184

Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome

Clinical TrialPMID: 21317170

Teduglutide in short bowel syndrome patients: A way back to normal life?

ReviewPMID: 34614239

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

Related Peptides

Quick Facts

Class
GLP-2 Analogue
Evidence
Strong
Safety
Well-Studied
Updated
Mar 2026
Citations
31PubMed

Also known as

GattexRevestive

Tags

FDA-ApprovedGut HealthIntestinal Growth

Related Goals

Evidence Score

Overall Confidence90%

Clinical Trials

View Clinical Trials

Links to ClinicalTrials.gov for reference. Listing does not imply endorsement.

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