Teduglutide
An FDA-approved GLP-2 analogue that promotes intestinal growth, used for short bowel syndrome.
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What is Teduglutide?
Teduglutide is a GLP-2 (glucagon-like peptide-2) analogue that promotes intestinal mucosal growth and adaptation. It is FDA-approved for adults and children with short bowel syndrome (SBS) who are dependent on parenteral nutrition. It is the first drug to address the underlying intestinal insufficiency rather than just managing symptoms.
Why People Talk About It
Short bowel syndrome treatment
StrongReducing parenteral nutrition dependence
StrongIntestinal mucosal growth and repair
StrongHow It Works
Teduglutide tells the intestinal lining to grow. For patients who have lost most of their intestine, it helps the remaining gut tissue become more efficient at absorbing nutrients and fluids.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Requires colonoscopy before and during treatment (theoretical polyp risk)
- • Monitor for biliary and pancreatic disease
- • Adjust parenteral nutrition as absorption improves
What We Don't Know
Long-term effects on intestinal neoplasia risk are being monitored through registries.
Published Research
31 studiesPositive clinical outcomes associated with use of glucagon-like peptide-2 (GLP-2) analogues in patients with intestinal failure: A systematic review and meta-analysis
Efficacy and safety of glucagon-like peptide 2 in patients with short bowel syndrome: a systematic review and network meta-analysis
[Review of real-life teduglutide experience]
Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis
Population pharmacokinetics of teduglutide following repeated subcutaneous administrations in healthy participants and in patients with short bowel syndrome and Crohn's disease
Use of Teduglutide in Children With Intestinal Failure: A Systematic Review
Teduglutide for Safe Reduction of Parenteral Nutrient and/or Fluid Requirements in Adults: A Systematic Review
Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration
Teduglutide improves liver chemistries in short bowel syndrome-associated intestinal failure: Post hoc analysis
Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial
Efficacy and Safety of Teduglutide in Infants and Children With Short Bowel Syndrome Dependent on Parenteral Support
Teduglutide for the treatment of low-output enterocutaneous fistula - A pilot randomized controlled study
Citrulline correlations in short bowel syndrome-intestinal failure by patient stratification: Analysis of 24 weeks of teduglutide treatment from a randomized controlled study
Impact of Teduglutide on Quality of Life Among Patients With Short Bowel Syndrome and Intestinal Failure
Glucagon-like peptide-2 mobilizes lipids from the intestine by a systemic nitric oxide-independent mechanism
Reduction of Parenteral Nutrition and Hydration Support and Safety With Long-Term Teduglutide Treatment in Patients With Short Bowel Syndrome-Associated Intestinal Failure: STEPS-3 Study
Factors Associated With Response to Teduglutide in Patients With Short-Bowel Syndrome and Intestinal Failure
Independence From Parenteral Nutrition and Intravenous Fluid Support During Treatment With Teduglutide Among Patients With Intestinal Failure Associated With Short Bowel Syndrome
Patients With Short Bowel on Narcotics During 2 Randomized Trials Have Abdominal Complaints Independent of Teduglutide
Acute Effects of a Glucagon-Like Peptide 2 Analogue, Teduglutide, on Gastrointestinal Motor Function and Permeability in Adult Patients With Short Bowel Syndrome on Home Parenteral Nutrition
A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects
Teduglutide enhances structural adaptation of the small intestinal mucosa in patients with short bowel syndrome
Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study
Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure
Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's disease
Pharmacokinetics, safety, and tolerability of teduglutide, a glucagon-like peptide-2 (GLP-2) analog, following multiple ascending subcutaneous administrations in healthy subjects
Teduglutide in pediatric patients under 10 kg with short bowel syndrome on parenteral support: An open-label study
Effects of Teduglutide on Diarrhea in Pediatric Patients with Short Bowel Syndrome-Associated Intestinal Failure
Teduglutide Reduces Need for Parenteral Support Among Patients With Short Bowel Syndrome With Intestinal Failure
Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
Teduglutide in short bowel syndrome patients: A way back to normal life?
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
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Quick Facts
- Class
- GLP-2 Analogue
- Evidence
- Strong
- Safety
- Well-Studied
- Updated
- Mar 2026
- Citations
- 31PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
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