Pinealon

A short tripeptide studied for neuroprotective and cognitive-enhancing properties, part of the Khavinson peptide bioregulator family.

PreliminaryLimited Data Beginner-Friendly

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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

What is Pinealon?

Pinealon is a tripeptide (Glu-Asp-Arg) developed by Vladimir Khavinson as part of his peptide bioregulator research. It is designed to target pineal gland and brain function, potentially supporting melatonin production, neuroprotection, and cognitive performance. As a short peptide, it can be taken orally and may cross the blood-brain barrier.

Why People Talk About It

Cognitive enhancement and clarity

Preliminary

Neuroprotection

Preliminary

Melatonin regulation support

Limited

Anti-aging brain support

Limited

How It Works

Pinealon is believed to support brain health by influencing gene expression in brain cells. As a tiny peptide, it can reach the brain and may help protect neurons and support the pineal gland's production of melatonin.

Common Questions

Safety Information

Important Safety Notes

Common Side Effects

Generally well-toleratedMild headache (rare)

Cautions

• Limited Western clinical data
• Not FDA-approved
• Most research from Russian institutions

What We Don't Know

Western validation of Khavinson's peptide bioregulator research is limited. Independent replication of results is needed.

Published Research

9 studies

[The peptide correction of neurotic disorders among professional truck-drivers]

Clinical TrialPMID: 23734521

EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease

ReviewPMID: 33396470

Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction

PreclinicalPMID: 30762356

[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia]

PreclinicalPMID: 28509493

[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon]

PreclinicalPMID: 25051764

Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins

PreclinicalPMID: 22977870

Pinealon protects the rat offspring from prenatal hyperhomocysteinemia

PreclinicalPMID: 22567179

Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes

PreclinicalPMID: 21978084

Regulatory peptides protect brain neurons from hypoxia in vivo

PreclinicalPMID: 21249538

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician