Selank
A synthetic peptide analog of tuftsin with anxiolytic and nootropic properties, developed in Russia.
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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
What is Selank?
Selank is a synthetic analog of the naturally occurring immunomodulatory peptide tuftsin, with an added Pro-Gly-Pro sequence for stability. Developed at the Institute of Molecular Genetics in Russia, it is approved there as a prescription anxiolytic (anti-anxiety) medication. It is discussed for its calming effects without the sedation or dependency associated with traditional anti-anxiety medications.
Why People Talk About It
Anxiety reduction without sedation
EmergingStress resilience
PreliminaryCognitive support during stress
PreliminaryImmune modulation
PreliminaryHow It Works
Selank works by modulating GABA, the brain's primary calming neurotransmitter, and by influencing serotonin metabolism. It essentially helps your brain's natural calming systems work more effectively without forcing them into overdrive.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Not FDA-approved in the US
- • Most clinical data from Russian studies
- • May interact with GABAergic medications
What We Don't Know
Western clinical trial data is very limited. Interactions with common Western medications are not well characterized.
Published Research
30 studies[Optimization of the treatment of anxiety disorders with selank]
[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]
[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]
[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]
[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA]
[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]
The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats
Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress
[The characteristics of the anxiolytic action of taftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity]
[Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress
Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank
Functional Connectomic Approach to Studying Selank and Semax Effects
Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment
Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats
Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress
Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism
Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons
Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice
The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action
Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation
The influence of Selank on the parameters of the hemostasis system, lipid profile, and blood sugar level in the course of experimental metabolic syndrome
[Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank]
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
Research Insights
Related Peptides
Quick Facts
- Class
- Nootropic Peptide
- Evidence
- Emerging
- Safety
- Moderate Data
- Updated
- Jan 2026
- Citations
- 30PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
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