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Selank

A synthetic peptide analog of tuftsin with anxiolytic and nootropic properties, developed in Russia.

EmergingModerate Data Beginner-Friendly

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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

What is Selank?

Selank is a synthetic analog of the naturally occurring immunomodulatory peptide tuftsin, with an added Pro-Gly-Pro sequence for stability. Developed at the Institute of Molecular Genetics in Russia, it is approved there as a prescription anxiolytic (anti-anxiety) medication. It is discussed for its calming effects without the sedation or dependency associated with traditional anti-anxiety medications.

Why People Talk About It

Anxiety reduction without sedation

Emerging

Stress resilience

Preliminary

Cognitive support during stress

Preliminary

Immune modulation

Preliminary

How It Works

Selank works by modulating GABA, the brain's primary calming neurotransmitter, and by influencing serotonin metabolism. It essentially helps your brain's natural calming systems work more effectively without forcing them into overdrive.

Common Questions

Safety Information

Important Safety Notes

Common Side Effects

Nasal irritationMild fatigueSlight sedation at higher doses

Cautions

  • Not FDA-approved in the US
  • Most clinical data from Russian studies
  • May interact with GABAergic medications

What We Don't Know

Western clinical trial data is very limited. Interactions with common Western medications are not well characterized.

Published Research

30 studies

[Optimization of the treatment of anxiety disorders with selank]

Randomized Controlled TrialPMID: 26356395

[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]

Randomized Controlled TrialPMID: 18454096

[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]

Clinical TrialPMID: 25176261

[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]

Comparative StudyPMID: 29787664

[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA]

Comparative StudyPMID: 19803361

[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]

Comparative StudyPMID: 18577961

The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats

Comparative StudyPMID: 14552529

Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress

Comparative StudyPMID: 14969422

[The characteristics of the anxiolytic action of taftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity]

Comparative StudyPMID: 8704608

[Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]

ReviewPMID: 16634437

Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats

PreclinicalPMID: 36322304

The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress

PreclinicalPMID: 32621722

Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank

PreclinicalPMID: 34396551

Functional Connectomic Approach to Studying Selank and Semax Effects

PreclinicalPMID: 32342318

Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank

PreclinicalPMID: 32651826

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

PreclinicalPMID: 31625062

State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

PreclinicalPMID: 31236882

Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress

PreclinicalPMID: 31243679

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity

PreclinicalPMID: 30255741

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells

PreclinicalPMID: 28293190

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

PreclinicalPMID: 28280289

Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress

PreclinicalPMID: 28853100

Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism

PreclinicalPMID: 28702721

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons

PreclinicalPMID: 28361410

Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice

PreclinicalPMID: 27878720

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action

PreclinicalPMID: 24291245

Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation

PreclinicalPMID: 24913576

The influence of Selank on the parameters of the hemostasis system, lipid profile, and blood sugar level in the course of experimental metabolic syndrome

PreclinicalPMID: 25371249

[Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank]

PreclinicalPMID: 24450168

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

PreclinicalPMID: 26924987

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

Research Insights

Related Peptides

Quick Facts

Class
Nootropic Peptide
Evidence
Emerging
Safety
Moderate Data
Updated
Jan 2026
Citations
30PubMed

Also known as

TP-7Selanc

Tags

AnxietyMoodCognitive SupportStress

Evidence Score

Overall Confidence50%

Clinical Trials

View Clinical Trials

Links to ClinicalTrials.gov for reference. Listing does not imply endorsement.

Clinician Guided

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