Sleep & Mood

Peptides explored for their potential effects on sleep quality, stress resilience, and emotional well-being.

13 peptides

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

Sleep and mood are foundational to health, and disruptions in either can cascade into numerous other issues. Several peptides have been studied for their potential to support sleep architecture, reduce anxiety, and improve stress resilience. Some work through direct neurochemical modulation, while others may improve sleep indirectly through growth hormone optimization.

Peptides for Sleep & Mood

CJC-1295

GHRH Analog

Beginner

A growth hormone-releasing hormone analog that stimulates the pituitary gland to produce more growth hormone.

Growth HormoneBody CompositionRecovery+2

ModerateModerate Data

Ipamorelin

Growth Hormone Secretagogue

Beginner

A selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin.

Growth HormoneBody CompositionRecovery+2

ModerateModerate Data

Semax

Nootropic Peptide

Beginner

A synthetic peptide analog of ACTH(4-10) developed in Russia, studied for cognitive enhancement and neuroprotection.

Cognitive SupportNeuroprotectionFocus+1

EmergingModerate Data

Selank

Nootropic Peptide

Beginner

A synthetic peptide analog of tuftsin with anxiolytic and nootropic properties, developed in Russia.

AnxietyMoodCognitive Support+1

EmergingModerate Data

Sermorelin

GHRH Analog

Beginner

A growth hormone-releasing hormone analog that was previously FDA-approved for diagnosing GH deficiency in children.

Growth HormoneAnti-AgingSleep+1

StrongWell-Studied

MK-677

Growth Hormone Secretagogue

An orally active growth hormone secretagogue that mimics ghrelin to stimulate GH and IGF-1 release.

Growth HormoneBody CompositionSleep+2

ModerateModerate Data

DSIP

Neuropeptide

A naturally occurring neuropeptide that modulates sleep patterns and has been studied for insomnia and stress.

SleepStressMood+1

EmergingLimited Data

PE-22-28

Neuroactive Peptide

A synthetic peptide derived from sortilin that acts as a TREK-1 channel blocker, studied as a rapid-acting antidepressant alternative.

MoodAntidepressantNeuroplasticity+1

PreliminaryLimited Data

CJC-1295 (no DAC)

GHRH Analog

Beginner

A modified growth hormone releasing hormone analog with a shorter half-life than DAC-conjugated CJC-1295, allowing more physiological GH pulsing.

Growth HormoneBody CompositionRecovery+1

ModerateModerate Data

N-Acetyl Selank Amidate

Nootropic Peptide

Beginner

An enhanced version of Selank with improved stability, studied for anxiety reduction and cognitive enhancement.

CognitiveAnxiolyticNootropic+1

EmergingModerate Data

Oxytocin

Neuropeptide Hormone

Beginner

A naturally occurring neuropeptide involved in social bonding, trust, and reproduction, FDA-approved for labor induction.

HormonalFDA-ApprovedSocial Bonding+1

StrongWell-Studied

Desmopressin

Vasopressin Analogue

Beginner

A synthetic analogue of vasopressin (ADH) FDA-approved for diabetes insipidus, bedwetting, and bleeding disorders.

HormonalFDA-ApprovedKidney

StrongWell-Studied

Orexin-A

Neuropeptide

A neuropeptide that regulates wakefulness, arousal, and appetite. Its deficiency causes narcolepsy.

SleepCognitiveWakefulness+1

EmergingLimited Data

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician