Sermorelin
A growth hormone-releasing hormone analog that was previously FDA-approved for diagnosing GH deficiency in children.
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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
What is Sermorelin?
Sermorelin is a synthetic peptide consisting of the first 29 amino acids of naturally occurring growth hormone-releasing hormone (GHRH). It was previously FDA-approved (as Geref) for diagnostic use in evaluating growth hormone deficiency in children. While the branded product was discontinued for commercial reasons, sermorelin remains available through compounding pharmacies and is one of the most well-studied growth hormone peptides.
Why People Talk About It
Growth hormone optimization
StrongImproved sleep quality
ModerateBody composition improvement
ModerateAnti-aging support
EmergingHow It Works
Sermorelin is essentially a copy of the natural signal your brain sends to release growth hormone. By providing this signal, it encourages your pituitary gland to produce more growth hormone naturally, rather than injecting growth hormone directly.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Requires clinician supervision
- • Monitor with IGF-1 levels
- • Not for those with active malignancies
What We Don't Know
While short-term safety is well established, long-term effects of sustained use for anti-aging purposes are less characterized.
Published Research
30 studiesInfluence of dopaminergic, adrenergic and cholinergic blockade and TRH administration on GH responses to GRF 1-29
Lack of effect of muscarinic cholinergic blockade on the GH responses to GRF 1-29 and TRH in acromegalic subjects
Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group
Effects of GRF (1-29) NH2 on short-term memory: neuroendocrine and neuropsychological assessment in healthy young subjects
A comparison of the biological activities of authentic rat GRF(1-43)OH with the analogue rat GRF(1-29)NH2
Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.
Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.
Site-specific PEGylation for high-yield preparation of Lys(21)-amine PEGylated growth hormone-releasing factor (GRF) (1-29) using a GRF(1-29) derivative FMOC-protected at Tyr(1) and Lys(12)
Interactions of GRF(1-29)NH2 with plasma proteins and their effects on the release of the peptide from a PLAGA matrix
The involvement of dipeptidyl peptidase IV in brush-border degradation of GRF(1-29)NH2 by intestinal mucosal cells
Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release
Histamine release on rat pleural and peritoneal mast cells elicited by human GRF(1-29)NH2
An analogue of growth hormone releasing factor (GRF), (Ac-Try1, D-Phe2)-GRF-(1-29), specifically antagonizes the facilitation of the flexor reflex induced by intrathecal vasoactive intestinal peptide in rat spinal cord
VIP antagonist [N-Ac-Tyr1,D-Phe2]-GRF-(1-29)-NH2: an inhibitor of vasodilation in the feline colon
[Effects of GRF 1-29 in normal and hypotrophic lambs]
The synthetic peptide GRF (1-29)-NH2 with growth hormone releasing activity penetrates human epidermis in nitro
Applications of BOP reagent in solid phase synthesis. Advantages of BOP reagent for difficult couplings exemplified by a synthesis of [Ala 15]-GRF(1-29)-NH2
GH response to GRF (1-29) NH2 in female rats treated neonatally with estradiol benzoate or testosterone propionate
[Influence of twice-daily injections of GRF 1-29 on production, feed intake and nutritional status of lactating goats]
Secondary structure of the human growth hormone releasing factor (GRF 1-29) by two-dimensional 1H-nmr spectroscopy
[Response of growth hormone to GRF(1-29)NH2 in 12 cases of active acromegaly]
Testing with growth hormone-releasing factor (GRF(1-29)NH2) and somatomedin C measurements for the evaluation of growth hormone deficiency
Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine
Does growth hormone releasing factor desensitize the somatotroph? Interpretation of responses of growth hormone during and after 10-hour infusion of GRF 1-29 amide in man
The effects of intranasal insufflation of growth hormone releasing factor analogue GRF 1-29 NH2 on growth hormone secretion in children with short stature
Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist
Structural requirements for the activation of rat anterior pituitary adenylate cyclase by growth hormone-releasing factor (GRF): discovery of (N-Ac-Tyr1, D-Arg2)-GRF(1-29)-NH2 as a GRF antagonist on membranes
A potentially effective drug for patients with recurrent glioma: sermorelin.
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
Research Insights
Related Peptides
CJC-1295
ModerateBeginnerA growth hormone-releasing hormone analog that stimulates the pituitary gland to produce more growth hormone.
Ipamorelin
ModerateBeginnerA selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin.
Tesamorelin
StrongAn FDA-approved GHRH analog used to reduce visceral fat in HIV-associated lipodystrophy.
Quick Facts
- Class
- GHRH Analog
- Evidence
- Strong
- Safety
- Well-Studied
- Updated
- Feb 2026
- Citations
- 30PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
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