DSIP
A naturally occurring neuropeptide that modulates sleep patterns and has been studied for insomnia and stress.
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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated in 1977 from the cerebral venous blood of rabbits during induced sleep. Despite its name, its relationship to sleep is more nuanced than simply 'inducing' it — it appears to modulate sleep architecture and stress responses rather than acting as a sedative. Multiple clinical trials in chronic insomnia patients and a pilot study in chronic pain have been conducted.
Why People Talk About It
Sleep quality improvement
EmergingStress response modulation
EmergingPain modulation
PreliminaryNeuroprotection (stroke recovery)
PreliminaryHow It Works
DSIP appears to work by modulating the brain's sleep-wake systems, potentially helping to normalize sleep patterns. Rather than forcing sleep like a sedative, it may help your brain's natural sleep architecture function more normally.
Common Questions
Safety Information
Common Side Effects
Cautions
- • Limited and sometimes contradictory research
- • Not FDA-approved
- • Mechanism not fully understood
What We Don't Know
The exact mechanism of action and optimal use parameters are not well established despite decades of research.
Published Research
41 studiesAn RCT study on the feasibility of anterior transpedicular screw fixation in the cervicothoracic junction
Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia
Different effects of delta-sleep-inducing peptide on arginine-vasopressin and ACTH secretion in normal men
Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man
Delta-sleep-inducing peptide does not affect CRH and meal-induced ACTH and cortisol secretion
Plasma concentration of nine hormones and neurotransmitters during usual activities or constant bed rest for 34 H
Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women
Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia
Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs
DSIP in insomnia
Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep
Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior
The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep
Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study
A clinical trial with DSIP
Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection
[Delta-sleep inducing peptide and the drug deltaran: possible approaches to antistress protection]
Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats
Decreased delta-sleep and plasma delta-sleep-inducing peptide in patients with Cushing syndrome
[The hypnogenic effects of delta sleep-inducing peptide (DSIP) analogs: a comparative study in rabbits and rats]
[Delta sleep-inducing peptide in the blood and hypothalamus of rats with various resistance to emotional stress]
Comparison of DSIP- (delta sleep-inducing peptide) and P-DSIP-like (phosphorylated) immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type, multi-infarct syndrome, communicating hydrocephalus and Parkinson's disease
Effects of DSIP, 5-HTP and serotonin on the lymphokine system: a preliminary study
Entry of DSIP peptides into dog CSF: role of physicochemical and pharmacokinetic parameters
Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP)
Development of an enzyme immunoassay for delta sleep-inducing peptide (DSIP) and its use in the determination of the metabolic clearance rate of DSIP administered to dogs
CSF-plasma relationships for DSIP and some other neuropeptides
The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide
Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?
[Endogenous anticonvulsants: neuropeptide Y and delta sleep inducing peptide]
Delta-sleep-inducing peptide (DSIP): a review
Delta sleep-inducing peptide (DSIP): a still unresolved riddle
Delta sleep inducing peptide inhibits somatostatin release via a dopaminergic mechanism
Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study.
Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP).
Delta-sleep-inducing peptide reduces CRF-induced corticosterone release.
Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.
Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude.
DSIP in the treatment of withdrawal syndromes from alcohol and opiates.
Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors.
Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial.
Always consult a qualified clinician
This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician
Related Peptides
Quick Facts
- Class
- Neuropeptide
- Evidence
- Emerging
- Safety
- Limited Data
- Updated
- Mar 2026
- Citations
- 41PubMed
Also known as
Tags
Related Goals
Evidence Score
Clinical Trials
View Clinical TrialsLinks to ClinicalTrials.gov for reference. Listing does not imply endorsement.
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