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DSIP

A naturally occurring neuropeptide that modulates sleep patterns and has been studied for insomnia and stress.

EmergingLimited Data

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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

What is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated in 1977 from the cerebral venous blood of rabbits during induced sleep. Despite its name, its relationship to sleep is more nuanced than simply 'inducing' it — it appears to modulate sleep architecture and stress responses rather than acting as a sedative. Multiple clinical trials in chronic insomnia patients and a pilot study in chronic pain have been conducted.

Why People Talk About It

Sleep quality improvement

Emerging

Stress response modulation

Emerging

Pain modulation

Preliminary

Neuroprotection (stroke recovery)

Preliminary

How It Works

DSIP appears to work by modulating the brain's sleep-wake systems, potentially helping to normalize sleep patterns. Rather than forcing sleep like a sedative, it may help your brain's natural sleep architecture function more normally.

Common Questions

Safety Information

Important Safety Notes

Common Side Effects

Generally well-tolerated in reported useMild drowsiness

Cautions

  • Limited and sometimes contradictory research
  • Not FDA-approved
  • Mechanism not fully understood

What We Don't Know

The exact mechanism of action and optimal use parameters are not well established despite decades of research.

Published Research

41 studies

An RCT study on the feasibility of anterior transpedicular screw fixation in the cervicothoracic junction

Randomized Controlled TrialPMID: 26931331

Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia

Randomized Controlled TrialPMID: 19142086

Different effects of delta-sleep-inducing peptide on arginine-vasopressin and ACTH secretion in normal men

Randomized Controlled TrialPMID: 7698722

Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man

Randomized Controlled TrialPMID: 2554357

Delta-sleep-inducing peptide does not affect CRH and meal-induced ACTH and cortisol secretion

Clinical TrialPMID: 7777652

Plasma concentration of nine hormones and neurotransmitters during usual activities or constant bed rest for 34 H

Clinical TrialPMID: 7895296

Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women

Clinical TrialPMID: 8475226

Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia

Clinical TrialPMID: 3622582

Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs

Clinical TrialPMID: 3583493

DSIP in insomnia

Clinical TrialPMID: 6391925

Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep

Clinical TrialPMID: 6689058

Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior

Clinical TrialPMID: 6895513

The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep

Clinical TrialPMID: 7028502

Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study

Clinical TrialPMID: 1299794

A clinical trial with DSIP

Clinical TrialPMID: 6391926

Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection

Comparative StudyPMID: 18975104

[Delta-sleep inducing peptide and the drug deltaran: possible approaches to antistress protection]

Comparative StudyPMID: 18427460

Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats

Comparative StudyPMID: 15911358

Decreased delta-sleep and plasma delta-sleep-inducing peptide in patients with Cushing syndrome

Comparative StudyPMID: 7700506

[The hypnogenic effects of delta sleep-inducing peptide (DSIP) analogs: a comparative study in rabbits and rats]

Comparative StudyPMID: 1455954

[Delta sleep-inducing peptide in the blood and hypothalamus of rats with various resistance to emotional stress]

Comparative StudyPMID: 3167172

Comparison of DSIP- (delta sleep-inducing peptide) and P-DSIP-like (phosphorylated) immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type, multi-infarct syndrome, communicating hydrocephalus and Parkinson's disease

Comparative StudyPMID: 2448424

Effects of DSIP, 5-HTP and serotonin on the lymphokine system: a preliminary study

Comparative StudyPMID: 3496316

Entry of DSIP peptides into dog CSF: role of physicochemical and pharmacokinetic parameters

Comparative StudyPMID: 3768731

Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP)

Comparative StudyPMID: 6548966

Development of an enzyme immunoassay for delta sleep-inducing peptide (DSIP) and its use in the determination of the metabolic clearance rate of DSIP administered to dogs

Comparative StudyPMID: 6379493

CSF-plasma relationships for DSIP and some other neuropeptides

Comparative StudyPMID: 6689211

The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide

Comparative StudyPMID: 862769

Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?

ReviewPMID: 19849801

[Endogenous anticonvulsants: neuropeptide Y and delta sleep inducing peptide]

ReviewPMID: 19102071

Delta-sleep-inducing peptide (DSIP): a review

ReviewPMID: 6145137

Delta sleep-inducing peptide (DSIP): a still unresolved riddle

ReviewPMID: 16539679

Delta sleep inducing peptide inhibits somatostatin release via a dopaminergic mechanism

PreclinicalPMID: 2886936

Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study.

Clinical TrialPMID: 6548970

Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP).

PreclinicalPMID: 2853064

Delta-sleep-inducing peptide reduces CRF-induced corticosterone release.

PreclinicalPMID: 2995861

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.

PreclinicalPMID: 34500605

Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude.

PreclinicalPMID: 30107169

DSIP in the treatment of withdrawal syndromes from alcohol and opiates.

Clinical TrialPMID: 6548969

Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors.

Clinical TrialPMID: 6328354

Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial.

Clinical TrialPMID: 9617990

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

Related Peptides

Quick Facts

Class
Neuropeptide
Evidence
Emerging
Safety
Limited Data
Updated
Mar 2026
Citations
41PubMed

Also known as

Delta Sleep-Inducing Peptide

Tags

SleepStressMoodNeuropeptide

Related Goals

Evidence Score

Overall Confidence35%

Clinical Trials

View Clinical Trials

Links to ClinicalTrials.gov for reference. Listing does not imply endorsement.

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