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N-Acetyl Selank Amidate

An enhanced version of Selank with improved stability, studied for anxiety reduction and cognitive enhancement.

EmergingModerate Data Beginner-Friendly

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This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

What is N-Acetyl Selank Amidate?

N-Acetyl Selank Amidate is a modified version of Selank with N-acetyl and C-amide terminal modifications that improve enzymatic stability and nasal absorption. Like standard Selank, it is a synthetic analogue of the naturally occurring immunopeptide tuftsin, with anxiolytic and nootropic properties.

Why People Talk About It

Enhanced anxiety reduction vs standard Selank

Emerging

Improved cognitive function and focus

Emerging

Better stability and bioavailability

Moderate

How It Works

This is a more stable version of Selank that helps reduce anxiety and improve mental clarity. It works by modulating GABA (the brain's calming neurotransmitter) and BDNF (a brain growth factor) without causing sedation or dependence.

Common Questions

Safety Information

Important Safety Notes

Common Side Effects

Generally well-toleratedMild nasal irritation (intranasal)Occasional fatigue

Cautions

  • Not FDA-approved
  • Limited data specific to the modified form
  • May interact with GABAergic medications

What We Don't Know

Safety data specific to the N-acetyl amidate form is limited. Extrapolated from Selank data.

Published Research

14 studies

[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]

Clinical TrialPMID: 18454096

SARS-CoV-2 Pandemic Impacts on NASA Ground Operations to Protect ISS Astronauts

PreclinicalPMID: 32971311

Hyperbaric hyperoxia alters innate immune functional properties during NASA Extreme Environment Mission Operation (NEEMO)

PreclinicalPMID: 26116982

Sleep research in space: expression of immediate early genes in forebrain structures of rats during the nasa neurolab mission (STS-90)

PreclinicalPMID: 17639784

Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV)

PreclinicalPMID: 11891860

Physical and biological studies with protons and HZE particles in a NASA supported research center in radiation health

PreclinicalPMID: 11770539

Erythroid cell growth and differentiation in vitro in the simulated microgravity environment of the NASA rotating wall vessel bioreactor

PreclinicalPMID: 11332741

Biological Macromolecule Crystallization Database, Version 3.0: new features, data and the NASA archive for protein crystal growth data

PreclinicalPMID: 15299394

Delivery of recombinant human growth hormone to rats during exposure to microgravity on NASA Space Shuttle Discovery

PreclinicalPMID: 1589535

Atriopeptin (AP-3) in atria and plasma of rats orbited aboard NASA Spacelab (SL3) for seven days

PreclinicalPMID: 2939472

EXPERIMENTAL INVESTIGATIONS ON ULTRA-LOW FREQUENCY DISPLACEMENT BALLISTOCARDIOGRAPHY. NASA TT F-269

PreclinicalPMID: 14292663

A critical study of the absorption of polypeptides in the far-ultraviolet as a means of extraterrestrial life detection. NASA TM X-1131

PreclinicalPMID: 5295056

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

PreclinicalPMID: 26924987

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

PreclinicalPMID: 28280289

Always consult a qualified clinician

This information is for educational purposes. Peptide therapy should be guided by a licensed healthcare provider. Connect with a Noho clinician

Research Insights

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Quick Facts

Class
Nootropic Peptide
Evidence
Emerging
Safety
Moderate Data
Updated
Mar 2026
Citations
14PubMed

Also known as

NASASelank Amidate

Tags

CognitiveAnxiolyticNootropicImmune

Evidence Score

Overall Confidence40%

Clinical Trials

View Clinical Trials

Links to ClinicalTrials.gov for reference. Listing does not imply endorsement.

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